Evaluation of efficacy and safety of pulsed inhaled nitric oxide

‪Martin Billger‬ - ‪Google Scholar‬

Birth Defects Research (Part C) 72:190–199, 2004. © 2004 Wiley‐Liss, Inc. There is increasing experimental evidence that cardiac endothelial cells regulate cardiac performance and that endothelin-1 (ET-1) is a central substance … Anthracyclines are widely used chemotherapeutic agents in the treatment of lymphomas known to induce cardiomyopathy in more than 20% of patients. At the same time, endogenous endothelin-1 acts through endothelial ET(B) receptors to stimulate formation of nitric oxide tonically and to oppose vasoconstriction. In view of the multiple cardiovascular actions of endothelin-1, there has been much interest in its … Endothelin was found to inhibit the secretion of parathyroid hormone from human adenoma cells and in an in vivo parathyroid gland perfusion model (78). These findings suggest that endothelin could have a regulatory function in parathyroid hormone secretion.

Endothelin 1 function

The ET α is located on vascular smooth muscle cells and ET β on vascular endothelial cells. The receptors function in opposition. Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer In this brief review, we present a comparative analysis of one molecule involved in craniofacial development, endothelin‐1, a small, secreted protein that is crucial for patterning the neural crest cells that give rise to lower jaw and throat structures.

Fysisk aktivitets reglering av cellbiologin bakom

Submitted av C Carlbom — Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation.

Fysisk aktivitets reglering av cellbiologin bakom

In patients with renal or cardiac failure, renal function may be endangered by elevated plasma concentrations of the vasoconstrictor endothelin-1 (ET-1). To mimic effects of pathologically increased plasma ET-1, we gave intravenous ET-1 in healthy subjects and examined whether simultaneous infusion of the ET A -receptor antagonist VML 588 would prevent the effects of ET-1 on the kidney.

In the cardiovascular system, ETs, particularly ET-1, are expressed in smooth muscle cells, cardiomyocytes, fibroblasts, and notably in vascular endothelial cells. Intense research over the last 10 years has changed the original view of ET-1 as mainly a vasoconstrictor regulating blood pressure, into a biological factor regulating processes such as Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. Generation of Hypo/Hypermorphic Mice for Endothelin-1. As a first step in generating modified forms of the Edn1 gene expressing low or high levels of endothelin-1 for use in studies of the effects of both loss of function and gain of function of endothelin-1, we first compared the relative effects on mRNA stability of the 3′ UTR of WT gene (Edn1) with a panel of other 3′ UTRs, as described Endothelins (ET) are known to regulate vascular function through interaction with G protein-coupled receptors.
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converts big endothelin-1 to endothelin-1.

Endothelins are implicated in vascular diseases of Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is strongly implicated in the pathogenesis of hypertension and endothelial dysfunction.
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Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which acts as the natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to vascular tone and regulates cell proliferation through activation of ETA and ETB receptors.

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Lisa Berglund - Research Scientist - Lund University LinkedIn

Wang JW(1), Li AY(2), Guo QH(3), Guo YJ(1), Weiss JW(4), Ji ES(5). Author information: (1)Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. The endothelins are widely distributed in tissues, produced by endothelial cells and many epithelial cell types.